CRL owns parts 1-8 of this collection, which comprises original correspondence, speeches, public and private papers, and personal records of the Prime Ministers of Great britain. Records were filemd from files of the Public Record Office, British Library, and other sources.

• Series 1: The Papers of William Pitt the Younger (Prime Minister, 1783-1801 and 1804-1806)  [catalog record] [Online Access]
• Series 2: The Papers of Sir Robert Peel (Prime Minister, 1834-1835, 1841-1845 and 1845-1846) [catalog record] [guide]
• Series 3: The Papers of Lord Liverpool (Prime Minister, 1812-1827)  [catalog record] [guide]
• Series 4: The Papers of the Duke of Newcastle (Prime Minister, 1754-1756 and 1757-1762)  [guide]
• Series 5: The Papers of Lord North (Prime Minister, 1770-1782)  [catalog record] [guide]
• Series 6: The Papers of George Grenville (Prime Minister, 1763-1765)  [catalog record] [guide]
• Series 7: The Papers of Spencer Perceval (Prime Minister, 1809-1812)  [catalog record] [guide]
• Series 8: The Papers of William Ewart Gladstone (Prime Minister, 1868-1874, 1880-1885, 1886, 1892-1894)  [catalog record]